Thomas Rivers and the EAE model
نویسنده
چکیده
Early vaccinations against viral diseases such as rabies occasionally resulted in “paralytic accidents”—central nervous system (CNS) complications in which inflammatory cells invaded the brain and demyelinating lesions ensued (1). These complications were widely attributed to an incomplete inactivation of the vaccine virus, which was grown in rabbit brain tissues. But there was another possible explanation: repeated injections of brain tissue might have triggered an allergic reaction.
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 202 شماره
صفحات -
تاریخ انتشار 2005